Abstract: The toxic effects of immunosuppressants are often dangerous factors which influence long term survival of recipients.  Individualized immunosuppressive therapy has been a hotspot and difficulty for comprehensive treatment of liver transplantation. Immunosuppressive therapy has been gradually  developed  to pursue long term survival for receipients and graft, minimized side effects of immunosuppressants, optimized quality of life of patients, and reduce the economic burden of patients. Through consideration of  patient′s  pathophysiological state,  understanding the characteristics and side effects of various  immunosuppressive, appropriate choose of the immune inhibitor, correct evaluation of immune state of recipients and graft, minimization of drug doses, individualized dosing regimen could be successfully carried out.